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Don Cheadle replaced Terrence Howard in the role of Rhodey after relations between Terrence and Marvel Studios deteriorated.
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Robert Downey Jr. recommended Justin Theroux to Jon Favreau as the film's screenwriter.
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The first sequel produced by Marvel Studios.
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The first sequel for Jon Favreau as both director and actor.
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Tony uses the phrase "ionized plasma," which sounds roughly like "wet water," since plasma is itself a fully ionized substance (most often a gas).
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The lithium dioxide mentioned in the film does not exist in nature.
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At the beginning of the film, several shots of a Moscow courtyard are shown, and next to it, along the road, a car is parked with Russian license plates that contain the English letters "w" and "s".
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At the end of the film, when the senator stands between Tony and Rhodey for a photo, Tony puts his hand on his back. In the next shot, Tony's hand is gone, and then it appears again.
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Al Pacino was considered for the role of Justin Hammer.
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Emily Blunt was supposed to play Black Widow, but she had to turn down the role due to her commitment to Gulliver's Travels (2010).