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The speed shown on the bus's speedometer (digitized in miles per hour) often did not match the bus's actual speed.
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When Jack crouches down to comfort Annie, the bus doors are visibly closed, but in the next shot of Jack, the doors are visibly open.
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When the bus circles in the airport, the middle doors are visibly open; when Jack approaches them to get off, they are closed, and he pushes them to open.
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The role of Jack was offered to Stephen Baldwin, William Baldwin, Johnny Depp, Bruce Willis, Tom Cruise, Jeff Bridges and Tom Hanks, but they all turned it down.
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Renny Harlin and Quentin Tarantino turned down directing the film.
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The film ranked 99th on the American Film Institute's list of the 100 most thrilling films.
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During filming, Keanu Reeves accidentally smashed the glass of a bus door, but in the end they decided to keep this episode in the film.
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Thirteen buses were used during filming, two of which were blown up.
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The model of the bus featured in the film is the GMC New Look.
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Jan de Bont cast Keanu Reeves as Jack Traven after seeing him in "Point Break" (1991).