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The film is based on Gillian Flynn's novel "Gone Girl" (2012).
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Reese Witherspoon, Charlize Theron, Natalie Portman, Emily Blunt, Rooney Mara, Olivia Wilde, Abbie Cornish and Julianne Hough were considered for the role of Amy Dunne.
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This is the first feature film shot entirely in 6K resolution (6144 x 3160).
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Although the film's events unfold in North Carthage, Missouri, filming took place in Cape Girardeau, Missouri. Extras were cast at the Rose Theatre at Southeast Missouri State University, which is also located in Cape Girardeau.
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Ben Affleck postponed work on his own film in order to work with David Fincher. Affleck said: "He is the only director I know who can do anyone's job better than the people who do it." Once on set, Affleck slightly changed the camera settings, having bet a crew member that Fincher wouldn't notice. But when filming began, Fincher immediately asked why the image looked a little dim.
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One of the film's scenes takes place in Missouri, in an abandoned shopping mall that has become something of a mecca for vagrants. These scenes were shot in Los Angeles: exterior shots were filmed near a closed Montgomery Ward store, while interiors were filmed in the huge Hawthorne Mall.
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Ben Affleck's birthday coincides with the birthday of his character Nick — August 15.
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Gillian Flynn, the author of the source novel, wrote several versions of the film's ending to maintain the interest of readers and viewers and to avoid spoilers.