Amy Marie Madigan (born September 11, 1950) is an American actress. She has performed on stage and in film, and has received a Golden Globe Award, an Academy Award nomination, as well as Emmy Award nominations. Since 1983 she has been married to actor Ed Harris.

Madigan made her film debut in the drama Love Child (1982), for which she was nominated for a Golden Globe Award in the category New Star of the Year – Actress. For her role as a woman in a difficult marriage in the drama film Twice in a Lifetime (1985), she received Academy Award and Golden Globe nominations for Best Supporting Actress. She also appeared in the films Love Letters (1984), Alamo Bay (1985), Nowhere to Hide (1987), Uncle Buck (1989), Field of Dreams (1989), Female Perversions (1996), Pollock (2000), and Gone Baby Gone (2007). After an absence of "significant roles," she drew attention again thanks to a role in the horror film Weapons (2025).

On television, Madigan played Sarah Weddington in the television film Roe vs. Wade (1989), for which she received a Golden Globe Award and was nominated for an Emmy Award. She also played roles in the HBO series Carnivàle (2003–2005), Grey's Anatomy (2008–2009), and Fringe (2009). On stage, she appeared in the off-Broadway production The Lucky Spot (1987), for which she was nominated for a Drama Desk Award for Best Actress in a Play, and in the 1992 Broadway production of A Streetcar Named Desire as Stella Kowalski.

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