Helena Mattsson (born March 30, 1984) is a Swedish actress living and working in Hollywood.

Mattsson was born and raised in Stockholm, Sweden, began performing in Wild Side Story and other cabarets early on, and moved to London, England at a young age to attend drama school. At 19, she moved to Hollywood. Her first role was in the short-lived television series Sweden, Ohio in 2004. In 2007 she appeared in the film Species: The Awakening and got a role in the film You and I. Mattsson also appeared in the Primal Scream music video for the song "Country Girl" in 2006. She appeared in the Touchstone Pictures film Surrogates, as well as in three episodes of the ABC series Desperate Housewives as Irina and in three episodes of Nikita as Cassandra Ovechkina. She played Alexis Blume in the television series 666 Park Avenue.