Stories from the set

At 00:07:50, Milla Jovovich can be seen wearing some kind of blue jacket (on her right shoulder), and in the next shot she is in a white sheet.

The film is based on the Resident Evil series of video games (1996 – present, Capcom).

Natasha Henstridge could well have played the role of Jill Valentine, but was unable to accept the offer due to more tempting offers. In the end, the role went to Sienna Guillory. The actress stated that she based her character's mannerisms and walk on her impressions of the video game of the same name.

"Nemesis" is the name of the third installment of the cult video game that inspired the work on this film. That was originally the title of the second part of "Resident Evil." A little later, the title was changed to the current one — "Resident Evil 2: Apocalypse," because in 2002 the film "Star Trek: Nemesis" was released.

Jason Isaacs could have played the role of Dr. Birkin, but dropped out of the project.

The trailer (promotional video) for this film became one of the most popular. Between November 2003 and May 2004, the video was downloaded by 8.5 million users.

The weapon called "Nemesis" (actually it is called the M134) is a development by General Electric. However, an exclusive variant was prepared specifically for the film.

The building that explodes in the film (of course, not for real) actually exists — it is the administrative center of Toronto.

Tobey Maguire and Josh Hartnett were supposed to play Chris Redfield and Leon Kennedy.

According to Paul Anderson (screenwriter and producer), the name of Dr. Isaacs (Iain Glen) is a tribute to actor Jason Isaacs, whose voice-over we can hear at the very beginning of the first film.