Clotilde Hesme (born 30 July 1979, Troyes, Aube) is a French actress. She is the sister of Annelise Hesme and Élodie Hesme, who are also actresses.

After studying at the National Higher Conservatory of Dramatic Art (CNSAD), she performed in plays and was noticed by Jérôme Bonnell, who cast her in his film "Olga's Chignon" in 2002. In 2005 she appeared in Philippe Garrel's film "Regular Lovers." She was nominated for the 2008 César Award in the category "Most Promising Actress" for her role in Christophe Honoré's film "Love Songs," and in the same year was nominated for the Molière Award for her role in Marivaux's play "The Second Surprise of Love." In 2009 she received the SACD Plaisir du théâtre prize.

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