Olisa Odele is an English actor. He played Yemi in all three seasons of the Channel 4 teen comedy drama Big Boys (2022–2025). As a child he appeared in forty episodes of the series My Parents Are Aliens (2004–2005).

Among his early television work are forty episodes of the series My Parents Are Aliens. He played Olu in Michaela Coel's series Chewing Gum on E4. He also appeared in the series It's a Sin. In 2019 he appeared in the BBC One comedy series Scarborough.

He played the lead role of Yemi in all three seasons of the Channel 4 teen comedy drama Big Boys created by Jack Rooke, and his performance was described as "regally characterful".

He played Peter in the 2024 British comedy series Dead Hot, released on Amazon Prime Video. In 2024 he appeared on stage as Isom in the National Theatre's British tour of the comedy play The Hot Wing King.