Andrey Gaydulyan was born in the city of Chisinau, Moldavian SSR, USSR, into a military family. During his school years he took part in a drama club led by Sergey Tiranin, an actor at the Chekhov Russian Drama Theater. In 2002, having arrived in Moscow, he applied to GITIS and to the Institute of Contemporary Art. He passed to the second round at GITIS. Since the exams at the two institutions were to take place at the same time, Andrey chose the ICA.

After graduating from the Institute of Contemporary Art, he performed at the Moscow theater "Glas". He appeared in episodic roles in several series. In November 2007, after passing an audition, he was approved for the role of Sasha in the sitcom "Univer".