Andrey Ivanovich Krasko was born in the city of Leningrad, RSFSR, USSR. His father was the actor Ivan Ivanovich Krasko, his mother was the teacher Kira Vasilyevna Petrova. Having failed to enter a theater institute on his first attempt, he worked for one season as a stagehand at the Komissarzhevskaya Theater. A year later he entered LGITMiK, into the workshop of Arkady Katsman and Lev Dodin. In 1979, after graduating from LGITMiK, he was assigned to the Tomsk Theater for Young Spectators. He worked at the theater in the city of Dimitrovgrad in Ulyanovsk Oblast, and at the St. Petersburg theater "Pritut Komedianta". He made his film debut in 1979 with an episodic role in the film "Personal Meeting", but he gained wide fame only in the late 1990s, thanks to his role in the TV series "National Security Agent" (1998-2004).

In 1982 he was drafted for compulsory service into the Soviet Army. He served in the air defense forces in Arkhangelsk Oblast. He was a TV host of the programs "Arsenal" on Daryal TV and "Who Is the Boss in the House" on the Kultura channel. In recent years he became one of the most popular and sought-after actors of the domestic cinema. He was married several times, both officially and in civil unions. Andrey Krasko's life ended tragically early. He died a little more than a month before turning 49. The fatal heart attack occurred during the filming of Sergei Ursulyak's film "Liquidation" near Odessa. The actor's funeral took place on July 7, 2006 at the Memorial Cemetery in the settlement of Komarovo near St. Petersburg.