Susi Sánchez is best known for her roles in Vicente Aranda's film "Mad Love," in which she played Queen Isabella I, and in the plays "Silver Face" and "The Women Who Dreamed of Horses." For these three roles she was nominated for the Spanish Actors and Actresses Union Awards, winning the award for best supporting actress for her performance in "Silver Face."

In 2015 she joined the cast of the television series "Charles, King-Emperor," playing Louise of Savoy.